AlphaSize Alpha GPC vs Choline

Put your “energy” drink down. Grab the container or spin the drink around and look at the supplement facts box. Do you see the ingredient AlphaSize®? Probably not, unless you are sipping on the new, Xendurance Focus drink.

Do you see the word Alpha-GPC or Choline in your ingredient list? If so, let’s discuss why you may want to switch to a drink containing AlphaSize®.


As we all search for the latest and greatest energy, focus and brain booster product, it is extremely rare to find AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) on a label. We will call it AlphaSize® A-GPC for short.

AlphaSize® A-GPC is recognized as the "premier" choline donor, especially compared to other forms of choline that offer reduced bioavailability. Therefore, AlphaSize® A-GPC is a very special nutrient that has been shown to significantly increase acetylcholine (AC) levels in the brain.

In fact, AlphaSize® A-GPC is considered to be one of the most effective brain nutrients in the world, and is used widely in clinical settings around the world involving memory.

AlphaSize® A-GPC also has an interesting utility in "mind-to-muscle" sports nutrition formulations, where it acts to optimize muscular power output, sharpen agility, and also delay mental fatigue. This is due to its action involving motor unit activation of muscle fibers and subsequent muscle contraction, as well as due to its mental sharpness benefits.

AlphaSize® A-GPC can physiologically outperform caffeine with respect to both mental and physical functions, with real measurable performance benefits.

So if the energy drink in your hand shows Alpha-GPC or Choline as a nootropic ingredient, what is the difference? The claims on the label and the website may show research for enhanced memory, clarity, focus, etc. Then why is AlphaSize® A-GPC so much better than just Alpha-GPC or Choline?

Good question. There are a few points to answer this. Out of all other choline sources CDP Choline is the only one that has the ability to influence the brain and provide benefit there. But AlphaSize® A-GPC’s claim is that it is more effective than CDP choline in doing this with ancillary benefits as well. So the issue is not necessarily to refute that CDP is not effective at all but that AlphaSize® A-GPC is much more effective. Here are a few facts that may get the points across because they have impact on the efficacy and costs.

  1. AlphaSize® A-GPC provides a 40% choline load by weight. CDP choline provides 22%. Meaning you must use roughly twice as much to achieve the same choline load. (Many studies test in this manner, using twice as much CDP choline and A-GPC still outperforms it significantly. )

    • Choline load is the true contributor to efficacy in both materials so this is key.

  1. AlphaSize® A-GPC consistently outperforms CDP choline in every study that we have seen whether oral or IM.

  2. AlphaSize® A-GPC works faster than CDP choline and is generally more thorough in its effects.

  3. AlphaSize® A-GPC has multiple other benefits that CDP choline has no proven efficacy for

    • Sports performance

    • Increased power output

    • HGH level increases

    To reiterate, you will find studies that show CDP choline has benefits for the brain but if the studies are direct comparisons for AlphaSize® A-GPC, CDP choline will be outperformed every time.

    AlphaSize® A-GPC is from Italy and they recommend a starting dose of 150mg. (active) If you see a choline source you may want to ask if it is from China, what type and how much of it is active? It is good to note that choline bitartrate is the least potent choline donor ingredient.

    Here is an overview on the scientifically validated and incredible benefits of AlphaSize® A-GPC:

    AlphaSize® A-GPC Overview:

    • The world’s most rapid and potent precursor of acetylcholine – the body’s primary neurotransmitter involved in cognition and muscle engagement.

    • FDA full GRAS – hence proven 100% safe for use in every formulation imaginable.

    • Supported by a USP Monograph (already in USP publication with full USP publication in December, 2019) – attesting to the absolute highest safety, quality, and regulatory standards.

    • Only brand of A-GPC validated by numerous research studies to improve memory, focus, recall, learning.

    • Also provide significant benefit to physical performance, power, strength, agility, eye hand coordination, gaming use.

    • Provides the most bioavailable source of choline – as demonstrated in numerous published papers.

    • Tasteless, colorless, odorless, 100% water soluble, and stable.

    • Demonstrated in published studies to outperform other choline sources.

    • Provides real, natural, energy, for people of all ages – better than caffeine, with no crash, and can replace or even boost caffeine.

    • Manufactured in a state-of-the-art, FDA inspected facility in Italy, and patent protected.

    • Mode of action: Potent natural precursor to immediate biosynthesis of acetylcholine and improved neuron function, better than CDP-choline (pub. papers show it), and the fact that choline bitartrate/chloride are not involved in brain metabolism (3 pub. papers show this).

    • Used widely for Alzheimer’s disease dementia, brain injury, and for improved mental performance in healthy persons.

    • Water soluble, IGEN Non-GMO Certified, non-soy.

    • Patented.

    • AlphaSize® A-GPC is the only one that has ever been tested in any study. Safe, no genotoxins or endotoxins, no AERs.


    • AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) Role In Brain And Muscle Recruitment Explained , Jan 15, 2019, Chem Nutra

    • Including validated claims support with references.

    • Hoffman, J., The effects of acute CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students., Jour. of the Intl. Society Of Sports Nutrn., 2010.

    • Parker, A., The effects of phosphatidylserine supplementation on cognitive functioning prior and following an acute bout of resistance training in young males., Jour. of the Intl. Society Of Sports Nutrn., 2010.

    • Parker, A., The Effects of Alpha-Glycerylphosphorylcholine, Caffeine or Placebo on Markers of Mood, Cognitive Function, Power, Speed, and Agility., 12th Annual Mtg. Intl. Society Of Sports Nutrn. Conf., 2015.

    • Ziegenfuss, T., AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) Administration And Changes In Growth Hormone And Power Output., 5th Annual Mtg. Intl. Society Of Sports Nutrn. Conf., 2008.

    • Ceda, G.P., Alpha-Glycerylphosphorylcholine Administration Increases the GH Responses to GHRH of Young and Elderly Subjects., Hormone Met. Resch. 24, 1992.

    • Kawamura, T., Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults., Nutrition, Elsevier, 2012.

    • Bellar, D., Alpha Glycerylphosphoryl Choline: Emerging Evidence for Ergogenic Potential., 13th Annual Mtg. Intl. Society Of Sports Nutrn. Conf., 2016.

    • Dechent, P., Neither Short-Term Nor Long-Term Administration of Oral Choline Alters Metabolite Concentrations in Human Brain., Biol. Psychiatry, 46: 406-411., 1999.

    • Lippelt, D.P., No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults., Plos One, DOI:10.1371/journal.pone.0157714. June 24, 2016.

    • Tan, J., Lack of Effect of Oral Choline Supplement on the Concentrations of Choline Metabolites in Human Brain., Huntington Medical Research Institute, Pasadena, CA, Williams & Wilkins, 1998.

    • Parnetti, L., et al., Cholinergic precursors in the treatment of cognitive impairment of vascular origin: Ineffective approaches or need for re-evaluation?, Jour. Neur. Sci. 257 (2007), 264-269.

    • Scapicchio PL., Revisiting choline alphoscerate profile: a new, perspective, role in dementia?, Intl. Jour. Neuro., 2013;123(7): 444-449.

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