The Need To Know on CBD

on October 14, 2019

CBD Oil is the latest product to explode onto the supplement landscape and with that explosion comes a lot of questions. Is CBD safe to take? How is it different from regular cannabis? Does it have legitimate health benefits for me or is this just another brand of Fit Tea?

As usual, Xendurance takes a painstaking approach to provide you with scientifically sound answers and the highest quality products available. Which is why after a prolonged buzz period, you’re finally seeing CBDeep Full Spectrum come to market. Let’s get into it.

What is CBD? Isn’t that just weed?

Cannabidiol or CBD is one of the two primary cannabinoids found in the cannabis sativa plant. It comprises roughly 40% of all cannabinoids in this species. The other primary substance in cannabis sativa is tetrahydrocannabinol (THC), the cannabinoid responsible for the psychoactive effects of the plant. These are separate compounds, and CBD exhibits none of the psychoactive effects found in THC. They do appear to share some of the same medical benefits, with a majority of current scientific research utilizing forms of cannabis possessing both compounds. Quality products, like CBDeep, possess 0.0 to 0.03% traces of THC, in accordance with Federal Law.

What’s the science?

There is currently a very limited scope of research done on isolated forms of CBD, when compared to the work done on cannabis containing THC. Most of what we do have has been done on animal subjects, which means a myriad of differences compared to the physiology of humans. This is largely due to the slow moving bureaucratic arms of Federal and State governments in figuring out exactly what to do about CBD, until developments within the last year or so. In fact until the 2018 Farm Bill was passed, growing hemp in the United States was incredibly difficult, with this non-psychoactive crop still considered a Schedule I narcotic.

The passing of the bill is largely responsible for the CBD boom in the past year. There’s no question that we need more research done, with a larger scope of subjects, and for greater lengths of time. And with the removal of hemp from the Schedule I list, we anticipate a rapid development in the literature, removing the taboo behind its study and greater availability of funding.

There are three specific conditions that the research behind CBD displays strong positive outcomes.

Epilepsy

A large body of the literature around CBD supports its implementation as a federally approved prescription medication to treat forms of Epilepsy. One drug is available specifically for this purpose: Epidiolex, an FDA approved prescription found in the United States. Clinical trials and metadata shows regular CBD usage significantly reduced the frequency of seizures, and the severity, in those with epilepsy and improved quality of life <1><2><3>. However, this is a serious medical condition that needs the regulation and dosing monitored by a medical professional. Do not self-medicate for epilepsy with CBD oil. Seek out your doctor for more on this, if you’re not already.

Autoimmune Disease

Studies also reveal positive effects in coping against the chronic pain associated with autoimmune diseases, such as multiple sclerosis (MS) and varying forms of arthritis <4><5>. Patients treated with CBD appeared to had greater pain relief and improved physical function as a result. Given the unpredictable nature of autoimmune diseases, consulting your physician about CBD usage for a general quality of life improvement might be helpful.

Anti-Inflammatory

This research brings exciting potential for general health and wellness. It’s thought the same mechanisms that appear to help these patients, can help athletes. Undergoing bouts of strenuous training is usually accompanied by high levels of inflammation. Application of CBD may help the highly active cope with acute pain and inflammation. A study utilizing a broader range of THC-free cannabinoids, inhibited the inflammatory mechanisms in humans associated with pain and swelling <6>. This data also supports what is known as the “entourage effect” in CBD, where the desired health benefits of CBD seem to come from a combined implementation of cannabinoids from the hemp plant. This is why CBDeep Full Spectrum is composed of this broad spectrum of oils.

Anti-Anxiety

One of the theorized primary functions of CBD is to combat the anxiety promoting psychoactive effects associated with THC usage <7>. This data is limited to studies where both substances are used in concert with varying results.

A few efforts focused specifically on CBD alone demonstrate its usefulness as an anti-anxiety application. In a controlled study, CBD performed similarly to anti-anxiety prescription drugs when used on subjects undergoing a simulated stress test <8>. This suggests CBD may be helpful in coping with acute bouts of high stress.

Safety and Quality

The studied threshold for safe ingestion of CBD is fairly high. The toxicity level is not quite well understood, but dosing as high as 1500mg of concentrated CBD has been demonstrated as clinically safe. That would mean ingesting 1.5 entire bottles of CBDeep Full Spectrum at once.

As with almost everything in the nutritional supplement landscape, not all products are created equal. A number of the early offerings available on the market heed no hazard in the extraction and manufacturing of their product. CBDeep Full Spectrum is a food grade oil extracted from U.S. grown, THC-free, whole-hemp plants, and manufactured using the same high standards demanded of all Xendurance products. Each batch is third-party tested to make sure there’s nothing in it that should be and the amount of available CBD is consistent with each bottle. No sketchy websites with unverified sources. No cringy social media influencer pitch. Just purity when it counts.


References

  1. Devinsky, O., Patel, A. D., Cross, J. H., Villanueva, V., Wirrell, E. C., Privitera, M., … Zuberi, S. M. (2018). Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome. New England Journal of Medicine, 378(20), 1888–1897. doi: 10.1056/nejmoa1714631

  2. Franco, V., & Perucca, E. (2019). Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy. Drugs, 79(13), 1435–1454. doi: 10.1007/s40265-019-01171-4

  3. Samanta, D. (2019). Cannabidiol: A Review of Clinical Efficacy and Safety in Epilepsy. Pediatric Neurology, 96, 24–29. doi: 10.1016/j.pediatrneurol.2019.03.014

  4. Wade, D. T., Robson, P., House, H., Makela, P., & Aram, J. (2003). A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clinical Rehabilitation, 17(1), 21–29. doi: 10.1191/0269215503cr581oa

  5. Philpott, H. T., Oʼbrien, M., & Mcdougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442–2451. doi: 10.1097/j.pain.0000000000001052

  6. Tagne, A. M., Marino, F., Legnaro, M., Luini, A., Pacchetti, B., & Cosentino, M. (2019). A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions. International Journal of Molecular Sciences, 20(8), 1833. doi: 10.3390/ijms20081833

  7. Boggs, D. L., Nguyen, J. D., Morgenson, D., Taffe, M. A., & Ranganathan, M. (2018). Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(1), 142–154. doi:10.1038/npp.2017.209l

  8. Zuardi, A. W., Cosme, R. A., Graeff, F. G., & Guimarães, F. S. (1993). Effects of ipsapirone and cannabidiol on human experimental anxiety. Journal of Psychopharmacology, 7(1_suppl), 82–88. doi: 10.1177/026988119300700112