As it relates to immunity, exercise can deliver a variety of messages. While regular and moderately intense activity has shown to help some athletes against some upper respiratory diseases (like the common cold), too much exercise has shown the opposite for other. In fact, they have notice too much exercise appeared to have negatively affected immunity.
As Dr. Jim Brown, Ph.D. references in his "How Exercise Affects Immunity" article in 2013, one clinical study found that 90 minutes or more of high-intensity exercise (marathons, endurance races) "does make a person more susceptible to illness for up to 72 hours after working out. During exercise, the body produces two hormones, cortisol and adrenaline, that raise blood pressure, elevate cholesterol levels, and temporarily weaken the immune system."
The heavy and long-term exercise could increase the amount of white blood cells and increase the presence of stress-related hormones that negatively impair the athlete's immunity system. For endurance athletes, the key to avoiding an impaired immune system is to allow your body and your immune system time to recover
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